MENT

guinea pig

Also seen as: Trestolone, 7a-methyl-19-nortestosterone, Trestolone Acetate

The Dose Guy’s verdict
Sep 1, 2026
4 sources

MENT is the most potent injectable most people will ever encounter, and it acts like it. A fraction of a testosterone dose delivers dramatic mass and strength, but it aromatizes into a potent estrogen, activates the progesterone receptor, and suppresses your natural production completely and fast. The human data is real but comes entirely from male-contraceptive research, not physique use. If you can manage estrogen and prolactin precisely and you have the experience to know why that matters, MENT rewards the effort. If any of that is new vocabulary, this is not your compound yet.

Would I take it?Caution, potent and unforgiving.

What it is

A synthetic 19-nor androgen originally developed as a male hormonal contraceptive. It sits in the same family as nandrolone and trenbolone, the 19-nortestosterones, but MENT is more potent per milligram than either, which is why the doses look small and the effects do not. It activates the androgen receptor far more powerfully than testosterone and, unlike trenbolone, it aromatizes, converting to 7-alpha-methyl-estradiol, an estrogen as potent as the natural one. It also activates the progesterone receptor as efficiently as progesterone itself. That combination of extreme androgenic potency, real estrogenic conversion, and progestogenic activity is what makes MENT both effective and demanding to run.

The contraceptive research explored it as a potential testosterone replacement that could suppress sperm production while maintaining androgen-dependent functions, and the implant trials showed it could do both. The bodybuilding community borrowed it from that research, running it as a mass compound at doses the researchers never tested.

What the research shows

MENT has more human data than most compounds this far down the shelf, but all of it comes from male hormonal contraception and hypogonadal-replacement trials, not physique research. The mechanism and potency are well characterized:

In cell transactivation assays, MENT was ten times more potent than testosterone and dihydrotestosterone at activating androgen receptor-driven gene expression. Its aromatized metabolite 7-alpha-methyl-estradiol showed estrogen activity similar to natural estradiol.Reprod Biol 2011 · in vitro
In a 35-man randomized implant trial, eight of 12 men receiving four MENT acetate implants reached azoospermia and one reached oligozoospermia.JCEM 2003 · phase 2 · n=35
In the Edinburgh group of a crossover trial in hypogonadal men, both MENT and testosterone enanthate increased sexual interest, sexual activity, spontaneous erections, and positive moods.JCEM 1999 · crossover · n=20
In the 48-week implant trial, hemoglobin rose and HDL cholesterol fell in both the MENT and testosterone groups.Hum Reprod 2007 · RCT · n=29 · 48 wk

Realistic protocols

MENT acetate is the ester most people run, and its short active life means daily injections, sometimes twice daily. The potency is extreme, so the doses look small next to testosterone but the effect is not. Start low and give each dose two to three weeks before judging it, because the estrogen and prolactin effects take time to stabilize and can ambush you if you jump too fast.

Estrogen management is not optional. MENT aromatizes to a potent estrogen that standard blood panels may not fully capture. Run an aromatase inhibitor from the start and titrate by symptoms: water retention, sensitive nipples, and emotional volatility mean adjust the AI dose or lower the MENT until symptoms settle. Prolactin management matters too, the same as with nandrolone. Cabergoline or P5P, keeping prolactin in range, because the progesterone receptor activity will push it.

Daily injections are a routine commitment. Pin at the same time each day to keep levels stable, because the trial data shows libido crashes when MENT levels drop. Alcohol compounds the lipid strain. If sleep or mood deteriorates, check your estrogen management first.

Some experienced users run MENT as a testosterone replacement, solo at low doses, for the reported improvements in well-being and libido. The one trial that tried it, two implants in hypogonadal men for 24 weeks, maintained most androgen-dependent functions but did not maintain bone mass. Running MENT solo may cost your skeleton. The more common community approach is stacking it with a testosterone base at a modest dose and letting MENT do the heavy lifting for the cycle. Either way, MENT suppresses your own production completely and fast. Plan the PCT before you start, or accept that you are staying on.

Entry5–10 mg/dayDaily sub-q or shallow IM. The potency data puts this near a heavy testosterone dose. AI from day one.
Moderate blast10–25 mg/dayWhere most users find the sweet spot for mass. Estrogen and prolactin demand attention.
High25–50 mg/dayAdvanced only. Side management becomes the full-time job.

Side effects

The potency cuts both ways, and every side scales with the dose:

commonRapid estrogen rise from aromatization to 7-alpha-methyl-estradiol. Water retention, mood swings, and gynecomastia risk if AI management is not dialed in early.
monitorComplete suppression of natural testosterone, faster and deeper than most compounds. Plan the exit before the entry: PCT or acceptance that you are on TRT for life.
monitorProlactin elevation from progesterone receptor activity. Monitor with bloodwork. Cabergoline or P5P keeps it in range.
monitorHemoglobin rise and HDL suppression documented in the 48-week trial. Blood pressure elevation reported at higher community doses.

Where to buy

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