DADA
guinea pig
The Dose Guy’s verdictOct 27, 20263 sources
Interesting chemistry, wrong receipts. DADA is sold as metabolic fuel for energy and endurance, and nobody has tested it in a person for either. Its one real human trial is in fatty liver, and everything else is cells, mice, and a few horses. I would not run it. If you want a mitochondrial energy experiment, MOTS-c has more behind it, and if you run DADA anyway, stay inside the liver trial’s doses, go short, and stop at the first tingle in your hands or feet.
What it is
A salt with two halves: dichloroacetate, the active part, and diisopropylamine. Dichloroacetate blocks pyruvate dehydrogenase kinase, an enzyme that keeps the door into your mitochondria half closed. With that brake off, more of the pyruvate from burned sugar goes into the mitochondria for aerobic energy and less gets dumped as lactate. That is the whole endurance pitch: less lactate, more aerobic burn. DADA is a liver drug in parts of Asia and was a component of the Soviet-era pangamic acid products sold to athletes as vitamin B15, a vitamin that does not exist.
Most of the real research is cancer work in mice, which is how it ended up in the same forum threads as fenbendazole. On the energy shelf it sits next to MOTS-c and mildronate, and it has the newest story and the least human evidence of the three. Online it moves as a research chemical, with all the purity guesswork that implies.
What the research shows
One human trial, in fatty liver, and nothing in people for the energy and endurance use it is sold for:
Realistic protocols
There is no energy protocol to give you, because nobody has measured one. The only human dosing on record is the fatty liver trial, 60 to 120 mg a day by mouth for 8 weeks, and that tells you what livers tolerated, not what does anything for your training. If you run it anyway, stay inside that range, go short, and treat it as weeks, not months. Run it alone so you can tell what it did, and log energy, training, and sleep. Stop at the first tingling, numbness, or burning in your hands or feet; that is the documented price of dichloroacetate in people. And if you came here from a cancer forum with fenbendazole in the cart: a mouse tumor study is not a treatment plan. Keep your oncologist in the loop.
Side effects
The fatty liver trial is the only human safety read, eight weeks long, so the rest borrows from DADA’s active half:
