DOSEGUY

RGPU-95

guinea pig

Also seen as: p-Cl-Phenylpiracetam

The Dose Guy’s verdict
Sep 1, 2026
1 source

RGPU-95 has a single rat study and nothing else. No human data, no PK, no safety profile. The one study found it more anxiolytic than phenylpiracetam and comparable to imipramine as an antidepressant, which is interesting on paper. One rat paper is not something I can build a recommendation on. If you are curious about this corner of the racetam family, phenylpiracetam itself has more behind it.

Would I take it?One rat study, that's the whole file.

What it is

A para-chloro analog of phenylpiracetam from the Russian racetam research pipeline. One published study compared it to phenylpiracetam and diazepam for anxiolytic effects and to imipramine for antidepressant effects, all in rats. RGPU-95 showed greater anxiolytic activity than phenylpiracetam but lower anxiolytic activity than diazepam, and antidepressant activity comparable to imipramine. That is the entire scientific record. As a research chemical it sits at the far edge of the racetam family, where the compounds grow increasingly obscure and the data increasingly absent.

What the research shows

No human trials. Zero. Everything below is animal or in-vitro work. Read it as “interesting,” not “evidence it works in you.”

One rat study, no human data of any kind:

RGPU-95 showed significantly greater anxiolytic activity than Fenotropil in rats.Eksp Klin Farmakol 2010 · rat study
RGPU-95 showed antidepressant activity comparable to Melipramin in rats, with effects more pronounced in males than females.Eksp Klin Farmakol 2010 · rat study
No human study, pharmacokinetic data, or safety study of RGPU-95 exists in the indexed literature.as of Aug 2026

Realistic protocols

There is no human dosing data for RGPU-95. I cannot build a protocol from one rat behavioral study that never measured oral absorption or blood levels. If you source it and run it anyway, the only sensible starting point is to treat it like phenylpiracetam at a conservative dose, since the rat study showed greater activity than phenylpiracetam but no dose comparison exists. Keep the run very short. Log everything. You are the study.

Side effects

No human data exists:

monitorThe rat study showed anxiolytic and antidepressant activity. Sedation and mood changes are plausible but unmeasured in humans.
unknownZero human safety data. Every side effect is unmeasured, not absent.
unknownCommunity experience with RGPU-95 is essentially nonexistent. You will find almost nothing to reference.

Where to buy

No live listings from tracked vendors right now.