DOSEGUY

Arimistane

weak data

Also seen as: androsta-3,5-diene-7,17-dione, 3-deoxy-7-oxo-DHEA

The Dose Guy’s verdict
Sep 1, 2026
1 source

A genuinely mild aromatase inhibitor sold as a supplement. If bloodwork shows estrogen slightly elevated and you want an accessible nudge, arimistane is the gentle option. If you need real estrogen control on a testosterone or other aromatizing cycle, skip it and use anastrozole or exemestane. There is no human efficacy data behind arimistane. None.

Would I take it?Fine for a nudge, not for the real job.

What it is

A DHEA-derived steroidal aromatase inhibitor that works through the same suicidal mechanism as exemestane, permanently disabling the aromatase enzyme on contact. The difference is potency: arimistane is far weaker, sold as a supplement in the US despite sitting on the WADA banned list. The only published human data is antidoping metabolism work, not an efficacy trial, and the Research receipt tells the rest of that story.

The community runs it for mild estrogen management or as a standalone for guys who want a slight nudge without a prescription. One common use case is after a SARM cycle, but be careful there: coming off a suppressive SARM your testosterone is already low, which means estradiol is already low, and adding any aromatase inhibitor on top is how people end up with crashed joints and flat mood during recovery. If bloodwork shows estrogen genuinely elevated, fine. If you are guessing, skip it. For anything that requires real estrogen control, anastrozole or exemestane does the job and has the data behind it.

What the research shows

No human trials. Zero. Everything below is animal or in-vitro work. Read it as “interesting,” not “evidence it works in you.”

The published literature on arimistane is entirely antidoping metabolism work. There are no efficacy trials and no controlled safety data:

A single oral 25 mg dose in three healthy volunteers produced no relevant effects on the steroid profile parameters studied.RCM 2019 · single dose · n=3
No human trial evaluating repeated arimistane dosing, physique outcomes, or PCT efficacy exists in the PubMed corpus.as of Aug 2026
No controlled human safety trial of repeated arimistane dosing and no published adverse-event rate.as of Aug 2026

Realistic protocols

The community runs 25 to 75 mg daily for four to six weeks, typically after a SARM cycle or as standalone estrogen management. There is no clinical dosing data behind this, so the protocol is crowd-sourced experience. Start at 25 mg daily, assess after a couple of weeks, and only move up if you have a specific reason. Higher doses do not guarantee more effect because nobody has measured the dose-response curve in humans.

If you are running an actual anabolic steroid cycle with real aromatization, arimistane is not the answer. You will not control meaningful estrogen elevation with a supplement-grade AI. Get bloodwork, and if estrogen is a problem, use a real aromatase inhibitor.

Light use25 mg/dayFor a mild estrogen nudge when bloodwork confirms elevated estradiol.
Moderate50–75 mg/dayHigher end, unproven. Nobody has measured whether more does more.
Duration4–6 weeksTypical community run. No data to guide cycling.

Side effects

The safety data is a blank page. Community reports exist, but nothing has been measured:

anecdotalHeadache and minor mood shifts, reported occasionally at higher doses.
anecdotalMild lethargy, usually transient.
unknownNo controlled safety data for repeated dosing exists. The real risk is not what arimistane does to you, it is what it fails to do: thinking your estrogen is controlled when it is not.

Where to buy

No live listings from tracked vendors right now.