DOSEGUY

Aminotadalafil

guinea pig

Also seen as: amino tadalafil

The Dose Guy’s verdict
Oct 27, 2026
3 sources

Skip it. Aminotadalafil is a knockoff of tadalafil that mostly shows up where it shouldn’t: hidden in “natural” sex supplements and, once, in e-cigarette cartridges. No human trial has ever tested it, so nobody knows its dose, its strength or what it does to you. Real tadalafil is cheap, proven and does the same job.

Would I take it?No, buy real tadalafil.

What it is

A chemical cousin of tadalafil, tweaked just enough to sit outside the approved-drug rules. That’s its reason to exist: supplement makers slip analogs like this into herbal pills so the box can promise results without listing a drug. Chemists find it by taking those products apart, and that is the only place it appears in the literature. Some sellers now offer it outright as a research chemical, pitched as tadalafil without the prescription. It presumably blocks PDE5 like its parent, but presumably is all anyone has.

What the research shows

No human trials. Zero. Everything below is animal or in-vitro work. Read it as “interesting,” not “evidence it works in you.”

Every paper on aminotadalafil is a lab identifying it in a product that didn’t declare it. That’s the whole evidence base:

Lab analysis found aminotadalafil as the major compound in an erectile dysfunction supplement sold in Argentina, an unapproved PDE5 analog under a supplement label.J Sex Med 2015 · lab analysis
Chemists identified it in electronic cigarette cartridges.J Chromatogr A 2010 · lab analysis
One illegal health food held a reaction product of aminotadalafil and a filler ingredient, probably from the two reacting inside the product. Nobody designed or tested that molecule either.J Pharm Biomed Anal 2010 · lab analysis
No human trial, no human pharmacokinetic measurement and no human safety data exist for aminotadalafil.as of Oct 2026

Realistic protocols

I’m not giving you a dose for a molecule nobody has dosed in a person. Sellers label it to mirror tadalafil, but with zero human pharmacology, milligram for milligram means nothing: it could be weaker, stronger or longer-lasting. A COA tells you what’s in the vial, not what it does inside you. If you want what this promises, run real tadalafil, a low daily dose or a bigger one when you need it, a prescription away. And if a “natural” sex pill ever worked suspiciously well for you, assume it hid a PDE5 analog and treat it like one: never with nitrates.

Side effects

Nobody has measured a single side effect in a human, so this is inference and anecdote:

anecdotalExpect the PDE5 basics, headache, flushing and a stuffy nose, if it really acts like its parent.
unknownIts strength and how long it lasts in you. An unknown dose of an unknown-potency PDE5 is how you get a four-hour erection or a blood pressure drop you didn’t plan for.
monitorTreat it as a PDE5 until proven otherwise: never with nitrates, prescription or poppers.

Where to buy

Disguised Research–
$79.99 / unit
✓ verified Oct 31
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