DOSEGUY

LGD-3303

guinea pig

Also seen as: LGD3303, LGD 3303, LGD

The Dose Guy’s verdict
Sep 1, 2026
2 sources

LGD-3303 has the sharpest muscle-versus-prostate separation I have seen in a published SARM: muscle above intact levels, prostate under half of normal, even at high doses. That is impressive, and it is entirely in a rat. No human trial, no human pharmacokinetics, no safety profile in a person. If you want the LGD profile, ligandrol has actual clinical data behind it. LGD-3303 is the promising cousin that never left the lab.

Would I take it?Not without a single human dose.

What it is

Ligand Pharmaceuticals ran three SARMs through development. LGD-2226 was shelved early, ligandrol reached the clinic, and LGD-3303 stayed in the lab with the most compelling rat data of the three. In binding assays it is potent and highly selective, with minimal cross-reactivity at other nuclear receptors. It also crosses the blood-brain barrier, which led to behavioral studies in female rats where it influenced sexual preference through a pathway that required an intact androgen receptor. None of this has been tested in a person.

What the research shows

No human trials. Zero. Everything below is animal or in-vitro work. Read it as “interesting,” not “evidence it works in you.”

Strong rat pharmacology. The evidence stops there:

In orchidectomized male rats treated orally for 14 days, LGD-3303 raised levator ani weight, the standard rat marker of anabolic activity, above eugonadal levels while ventral prostate weight remained below 50% of those intact-animal levels even at high doses.JBMR 2009 · rat · receptor + bone
Tissue selectivity was not explained by drug distribution: prostate had higher LGD-3303 concentrations than muscle, despite the muscle showing the stronger androgenic response.JPET 2009 · rat PK/PD
No human clinical study of LGD-3303 exists in the published literature.as of Aug 2026

Realistic protocols

No human dose exists in the literature. A small underground community has experimented with roughly 10 to 20 mg daily for six to eight weeks, treating it like a stronger ligandrol. There is no human PK to tell you how it absorbs, how long it lasts, or where it concentrates in a person. If you run it: a third-party COA first, because what sells as LGD-3303 on the grey market could easily be something else. Bloodwork before and after covering testosterone, lipids, and liver. Plan for PCT, because a compound this androgenic in rats will suppress your own production. Every SARM is prohibited in tested sport.

Side effects

No human adverse events on record. The expectation is shaped by the class and the potency in animals:

anecdotalTestosterone suppression. Given the potency in rat models, expect this to be meaningful, not mild.
anecdotalUsers describe a dry, hard feel similar to winstrol. I would expect a lipid hit from a compound this androgenic in rats.
unknownNo human safety data. No liver, lipid, or cardiovascular profile exists in a person.

Where to buy

No live listings from tracked vendors right now.