DOSEGUY

Fladrafinil

guinea pig

Also seen as: CRL-40,941

The Dose Guy’s verdict
Sep 1, 2026
1 source

Fladrafinil is a prodrug that your liver converts to flmodafinil, which is itself a fluorinated modafinil analog with no efficacy data. So you’re adding a conversion step to reach a compound that hasn’t been studied for the thing you’re buying it for. The one human study that exists dosed a few volunteers at 20 mg for anti-doping detection, not wakefulness. No efficacy trial, no safety study, no dose-ranging work. If you want the modafinil effect without a prescription, adrafinil has the same prodrug logic with more data behind it, though it taxes the liver on conversion.

Would I take it?Probably not. A prodrug for something that barely has data itself.

What it is

Fladrafinil is a fluorinated structural analog of modafinil that acts as a prodrug for flmodafinil. You swallow fladrafinil, your body converts it to flmodafinil, and from there the metabolic path mirrors the modafinil family: flmodafinil acid and flmodafinil sulfone show up in blood and urine. The conversion adds a delay before the active compound peaks, which means slower onset than taking flmodafinil directly. The entire modafinil-analog tail, fladrafinil, flmodafinil, hydrafinil myristate, sits in the same gray-market space: research chemicals sold as wakefulness upgrades on the strength of structural similarity to a proven drug, without the clinical work to back the upgrade story.

What the research shows

No human trials. Zero. Everything below is animal or in-vitro work. Read it as “interesting,” not “evidence it works in you.”

The published evidence is almost entirely about detecting the compound in drug tests, not about whether it works:

In a study where six volunteers each ingested 20 mg of either fladrafinil or flmodafinil, fladrafinil converted to flmodafinil with a slight delay before peak concentration, confirming the prodrug relationship. Maximum blood concentrations ranged from 11 to 35 ng/mL for fladrafinil and 45 to 98 ng/mL for flmodafinil.Drug Test Anal 2026 · PK
No human trial of fladrafinil for cognition, wakefulness, fatigue, or any clinical outcome exists in the PubMed corpus.as of Aug 2026
No clinical safety study reporting adverse events, laboratory changes, or dependence risk for fladrafinil exists.as of Aug 2026

Realistic protocols

I can’t write a protocol grounded in evidence because no evidence-based dose exists. The community runs fladrafinil at roughly 50 to 150 mg orally for daytime wakefulness, treating it like a substitute for modafinil or adrafinil. Some users prefer it to adrafinil on the theory that the fluorinated end product is stronger, but that theory rests on structural reasoning, not on any study comparing the two. If you want this mechanism, adrafinil has real human data, though its liver cost is the tradeoff. Fladrafinil is a WADA class S6 prohibited stimulant and will flag on a drug test in competition. If you run fladrafinil anyway, expect a slower onset than flmodafinil due to the prodrug conversion, keep doses conservative, and don’t stack it with other stimulants.

Side effects

No safety data has been published. What follows is borrowed from the modafinil family and community reports:

anecdotalHeadache and mild nausea, the generic stimulant-family complaints, more common at higher doses.
anecdotalSleep disruption if taken after midday, expected from a compound that converts to an active eugeroic.
unknownNo human safety data of any kind. Fladrafinil adds a liver-conversion step to an unstudied end product. The modafinil class is generally well-tolerated, but that safety record belongs to modafinil, not to this analog.

Where to buy

All American Aminos–
$60 / unitblend
✓ verified Sep 12
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Disguised Research–
$74.99 / unit
⚠ ⚠ Unreachable since Sep 11
✓ verified Sep 8
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