SLU-PP-915
guinea pig
The Dose Guy’s verdictSep 1, 20264 sources
Skip it for now. SLU-PP-915 is the second-generation exercise mimetic from the ERR agonist family, a follow-on to SLU-PP-332 with better oral activity in mice and the same zero human mileage. The mechanism is genuinely interesting, telling cells to build mitochondria and burn fat the way training does, but nobody has tested it in a person. Watch the ERR space; do not volunteer as the trial.
What it is
A small molecule that activates all three estrogen-related receptors: ERR-alpha, ERR-beta, and ERR-gamma. Those receptors are the metabolic switches that flip when you exercise hard, driving mitochondrial biogenesis and fat oxidation in muscle and heart. SLU-PP-915 came out of the same Saint Louis University lab that built SLU-PP-332, redesigned to survive the gut and work when swallowed, where the original needed injection to reach useful blood levels.
The mouse work is clean. Oral SLU-PP-915 boosted exercise capacity, lit up the right gene targets, and both SLU-PP-915 and SLU-PP-332 improved cardiac function in a heart-failure model. But mice absorbing a research chemical and running farther on a treadmill is the opening chapter, not the ending. Human liver microsome work identified metabolites, but nobody has dosed a person. No safety profile, no efficacy signal in people. If weight loss is the actual goal, retatrutide and tirzepatide are a different planet of evidence.
What the research shows
All cells and mice. No human trial of any kind.
Realistic protocols
I’m not writing a dose for a compound with zero human data. The only metabolism work is in vitro: human liver S9 and microsome assays found seven phase-I transformation products and no phase-II products, which means nobody knows how your liver actually handles this at a real dose, how fast it clears, or what the metabolites do. If you run it anyway: source with a COA, start as low as you can measure, keep the run short, log everything, and get bloodwork before and after. You are the experiment, and there is no literature to bail you out if something goes wrong.
Side effects
No human has reported a side effect under controlled conditions:
